Efficacy of combination tablet of angiotensin receptor blocker and high dose calcium channel blocker in essential hypertension

Efficacy of combination tablet of angiotensin receptor blocker and high dose calcium channel blocker in essential hypertension - Efficacy of combination tablet of ARB and high dose CCB in essential hypertension

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000016704

Enrollment

Registered

2015-03-04

Start date

2014-01-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with essential hypertension

Interventions

Combination therapy of regular dose ARB and 5 mg of amlodipine is changed to therapy with combination tablet of regular dose ARB and 10 mg of amlodipine.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - patients with essential hypertension - poor blood pressure control under combination therapy of regular dose ARB and 5 mg of amlodipine

Exclusion criteria

Exclusion criteria: pregnant women or women who are possibly pregnant

Design outcomes

Primary

Measure	Time frame
blood pressure reduction	—

Secondary

Measure	Time frame
Changes in - endothelial function(FMD), atherosclerosis (CAVI) - urinary protein and albumin and eGFR - uric acid - plasma renin activity, aldosterone, prorenin, and soluble (pro)renin receptor	—

Countries

Japan

Contacts

Public ContactSatoshi Morimoto

Tokyo Women's Medical University Department of Medicine II

smorimoto@endm.twmu.ac.jp03-3353-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026