Infants born with birth weight equal to or greater than 1500g, and less than 2000g
Conditions
Interventions
Bifidobacterium breve M-16V will be dissolved in water and amout of 0.5ml will be given within 24 hours after birth. The infants will receive probiotics once a day, for 21 days.
No application
Sponsors
Tokyo Metropolitan Childrens'medical center, department of Neonatology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Infants whose birth weight is equal to or greater than 1500g and less than 2000g, who were admitted to our hospital within 21 hours after birth.
Exclusion criteria
Exclusion criteria: Newborns with chromosomal anomaly, multiple congenital anomaly, congenital heart disease, congenital anomaly of intestine, and those who were judged inappropriate by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluate the fecal calprotectin concentration at day7 and day21. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the composition of intestinal flora on day0, 7, 21. Immunologic parameters such as fecal IgA concentration, serum cytokines, serum high sensitive CRP will be checked on day7 and 21. Body weight and feeding intolerance will be checked every day until day21. | — |
Countries
Japan
Contacts
Public ContactYuki Kimura
Tokyo Metropolitan Childrens'medical center Neonatology
Outcome results
None listed