None
Conditions
Interventions
The administration of the test food containing L-citrulline and L-arginine
The administration of the test food containing L-citrulline
The administration of the test food containing L-arginine
The adm
Sponsors
Soiken Inc.
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Healthy male subjects aged from 20 to 49 years old 2) Subjects whose BMI are 25 or over less than 30 kg/m2 3) Subjects who have a briefing of the content of the present study, fully understanding and agreeing to its objective and being able to personally sign a written informed consent
Exclusion criteria
Exclusion criteria: 1) Subjects who regularly take any drugs for cardiovascular or circulatory organs system 2) Subjects who have a history of heart diseases 3) Subjects who have severe liver, kidney, heart, respiratory, endocrine or metabolic diseases 4) Subjects who have a smoking habit 5) Subjects with a heavy alcohol consumption (>60 g/day) 6) Subjects who have an intake of Citrulline or Arginine 7) Subjects who take any drugs for improving circulating 8) Subjects who have the possibility of developing allergic symptoms by the test food 9) Subject having blood sample of 200 ml or more taken (e.g., donated blood) within 1 month, or 400 ml or more within 3 months prior to the start of the present study 10)Subject who took part in another clinical study within 3 months prior to the start of the present study or who is currently taking part in another clinical study 11) Subject deemed unsuitable by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood arginine and NOx levels | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood cGMP, 8-isoprostane, MDA-LDL, and triglyceride levels | — |
Countries
Japan
Contacts
Public ContactTomohiro Sugino
Soiken Inc. R&D Division
Outcome results
None listed