Non-inferiority trial of cardiovascular dynamics of lidocaine with adrenaline injection under general anesthesia between antipsychotics patients and control patients

Non-inferiority trial of cardiovascular dynamics of lidocaine with adrenaline injection under general anesthesia between antipsychotics patients and control patients - Cardiovascular dynamics of lidocaine with adrenaline injection to antipsychotics patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000016644

Enrollment

720

Registered

2015-04-01

Start date

2015-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients taking antipsychotics

Interventions

1)No premedication 2)Patients administer GA by TIVA (air, oxygen, propofol and remifentanil) 3)Take base line measurements if vital sign stable 4)One point eight ml lidocaine with adrenaline inject

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: dental patients under general anesthesia and dental patients he or she taking antipsychotics under general anesthesia

Exclusion criteria

Exclusion criteria: 1)ASA over 3 2)Taking circulation drugs 3)Taking tricyclic antidepressants 4)History of local anesthetics allergy 5)History of Hypertension, Arteriosclerosis, heart failure, hyperthyroidism, diabetes

Design outcomes

Primary

Measure	Time frame
1)Incidence of blood pressure decrease over 31 mmHg until 10 minutes after injection 2)Adverse event until 24 hours after injection	—

Secondary

Measure	Time frame
Abnormity of vital sign after injection	—

Countries

Japan

Contacts

Public Contactkatsuhisa sunada

Nippon Dental University dental anesthesiology

katsu.sunada@nifty.com03-3261-6064

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026