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Effect of an antipsychotic drug on regulatory system of salience network through dopamine D2/3 receptors

Effect of an antipsychotic drug on regulatory system of salience network through dopamine D2/3 receptors - Regulatory system of salience network through dopamine D2/3 receptors

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000016622
Enrollment
60
Registered
2015-04-01
Start date
2015-04-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schizophrenia

Interventions

magnetic resonance imaging, blood sampling magnetic resonance imaging

Sponsors

The Jikei University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: <schizophrenia> 1. Patients with schizophrenia diagnosed by DSM-IV-TR taking risperiodone 2. over 20 years old, less than 50 years old 3. male and female 4. Those who can read and understand informed consent of the protocol 5. Those who are treated by risperidone 6. Those who do not take benzadiazepines <healthy control> 1. Those who do not have psychiatric/severe physical disease 2. over 20 years old, less than 50 years old 3. male and female

Exclusion criteria

Exclusion criteria: <schizophrenia> 1. Those who have severe psychiatric symptom 2. Those who have other psychiatric disorder(s) 3. Those who have organic brain disease 4. Those who have severe physical disease 5. Those who pregnant or have a possibility of pregnancy 6. Those who have heart pace maker or other metal in their body 7. Those who have agrophobia 8. Those who have tatoo 9. Those who are considered as not eligible by principal investigator <healthy control> 1.Those who pregnant or have a possibility of pregnancy 2. Those who have heart pace maker or other metal in their body 3. Those who have agrophobia 4. Those who have tatoo 5. Those who are considered as not eligible by principal investigator

Design outcomes

Primary

MeasureTime frame
Relationship between functional connectivity in salience network and D2/3 receptor occupancy by risperidone in patients with schizophrenia.

Countries

Japan

Contacts

Public ContactKodaka Fumitoshi

The Jikei University School of Medicine Department of Psychiatry

kodaka@jikei.ac.jp+81-3-3433-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026