Open randomized controlled trial to evaluate efficacy of clindamycin in the pulmonary Mycobacterium avium complex disease

Open randomized controlled trial to evaluate efficacy of clindamycin in the pulmonary Mycobacterium avium complex disease - Open randomized controlled trial to evaluate efficacy of clindamycin in the pulmonary Mycobacterium avium complex disease

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000016615

Enrollment

100

Registered

2015-02-23

Start date

2015-02-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Mycobacterium avium complex disease

Interventions

Oral administration of clarithromycin, rifampicin, ethambutol. After oral administration of clarithromycin, rifampicin, ethambutol for month, add oral administration of clindamycin for two months. F

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients 20 years of age and older 2. Patients satisfying diagnostic riteria of nontuberculous mycobacteriosis and causative pathogens are Mycobacterium avium or M. intracellulare

Exclusion criteria

Exclusion criteria: 1. Patients receiving other antibiotic treatments. 2. Contraindication for clindamycin, clarithromycin, rifampicin, ethambutol administration 3. Patients deemed ineligible by the attending physicians for various reasons. 4. Patients with serious heart disorders

Design outcomes

Primary

Measure	Time frame
Findings of chest high resolution computed tomography before and after clindamycin treatment	—

Secondary

Measure	Time frame
1. Symptoms, laboratory data, spirometry 2. Bacteriological efficacy: sputum culture, and bacterial floral analysis findings of bronchoalveolar lavage fluid culture 3. Safety and adverse effects of clindamycin treatment	—

Countries

Japan

Contacts

Public ContactKei Yamasaki

University of Occupational and Environmental Health, Japan Department of Respiratory Medicine

kkyamsaki1019@yahoo.co.jp093-603-1611

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026