rheumatoid arthritis
Conditions
Interventions
* Evaluate the articular synovitis by gray and power dopplar scale using ultrasound (US). * Injection MTX (5mg/ml, 1ml) into MP or PIP joint using guide of US. After three minutes, perform electropo
Sponsors
Osaka City University Medical School, Department of Orthopedic Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: * Rheumatoid arthritis (RA) * No limitation of duration of RA * Patient who are recieving standard RA treatment * Patient who are stable disease activity during three months by Methotrexate * Patient who have swelling and tenderness at PIP or MP joint by positive power dopplar of ultrasound * Patient who are stable disease activity during three months by Steroid or biologic agent
Exclusion criteria
Exclusion criteria: * Patient who had a history of hypersensitivity for Methotrexate * Patient who have history of implantation and metallic material * Patient who had a significant unstable RA disease status * Patients who have infection disease * Patient who was pregnant, planning on becoming pregnant or breast feeding Patient who had a history of seizures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease activity of local inflammation by Visual Analogue Scale (VAS) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ultrasound assessment: Gray and power dopplar scale of local site. 2. Disease activity assessment: Mean value of DAS28, Mean change from baseline of DAS28. 3. Joint destruction: Change of modified Total Sharp Score (mTSS) from baseline. | — |
Countries
Japan
Contacts
Public ContactKentaro Inui
Osaka City University Medical School Department of Orthopedic Surgery
Outcome results
None listed