non-dialysis chronic kidney disease
Conditions
Sponsors
Kurume University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with CKD stage G3-G5 (eGFR< 60mL/min/1.73m2 ) not on dialysis 2) CKD-MBD patients without receiving phosphate binder treatment (%TRP<85% ) 3) Written informed consent
Exclusion criteria
Exclusion criteria: 1) <20years old 2) Treatment with lanthanum carbonate within the past two months 3) Contraindications to lanthanum carbonate 4) Inflammatory disease 5) Malignancy of any type 6) History of renal transplantation 7) Pregnant or breast-feeding women 8) Ineligible patients for this study according to the investigator's judgment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline and compare between 2 groups, as follows : Pulse wave velocity, Left ventricular mass and oxidative stress makers (nitrotyrosine, AGE, RAGE, Urinary 8-OHdG, Skin accumulation of AGE) | — |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline and compare between 2 groups, as follows: Phosphate, Calcium, FGF-23, soluble alfa-Klotho , iPTH, eGFR, Cr,1/Cr, OC, CRP | — |
Countries
Japan
Contacts
Public ContactKei Fukami
Kurume University School of Medicine Division of Nephrology, Department of Medicine
Outcome results
None listed