Non-small cell lung cancer
Conditions
Interventions
Sponsors
Shizuoka cancer center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Pathologically confirmation of non squamous non-small-cell lung cancer 2) EGFR mutation (exon 19 deletion or L858R in exon 21) proven 3) Stage IIIB/IV and chemo-naive non-small-cell lung cancer 4) ECOG PS 2 or 3 5) Evaluable lesions 6) Aged 20 or more 7) Adequate organ functions 8) Written informed consent
Exclusion criteria
Exclusion criteria: 1) EGFR mutation with T790M in exon 20 2) Uncontrolled symptomatic brain metastasis 3) Hemoptysis 4) Bleeding tendency 5) Use of antithrombotic agents 6) Evidence of tumor invading major blood vessel 7) Cavitated tumor 8) Thrombosis 9) Interstitial pneumonia or pulmonary fibrosis on imaging 10) Gastrointestinal disorder 11) Uncontrollable pleural effusion , ascites or pericardial effusion 12) Past given the radiation therapy for chest 13) Active double cancer 14) Severe complication 15) History of severe allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event, Response rate, Improvement rate of performance status, Overall survival | — |
Countries
Japan
Contacts
Public ContactKazuhisa Nakashima
Shizuoka cancer center Division of Thoracic Oncology
Outcome results
None listed