Effects of persimmon leaf tea intake on blood pressure and flow-mediated dilation levels; a dose finding study in subjects with high-normal blood pressure and mild hypertenssion

Effects of persimmon leaf tea intake on blood pressure and flow-mediated dilation levels; a dose finding study in subjects with high-normal blood pressure and mild hypertenssion - A dose finding study on effects of persimmon leaf tea intake on blood pressure and flow-mediated dilation levels

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000016432

Enrollment

Registered

2015-02-03

Start date

2015-02-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

No (subjects with systolic blood plessure 130-159 mmHg and diastolic blood pressure 85-99 mmHg)

Interventions

Pracebo drink, brawn-colored water (350ml/day) Persimmon leaf tea, low-dose (350ml/day extracted from 4g of the dried leaves) Persimmon leaf tea, high-dose (350ml/day extracted from 8g of the dried l

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Volunteers with high-normal blood pressure (SBP 130-139mmHg, DBP 85-89mmHg) and mild hypertenssion (SBP 140-159mmHg, DBP 90-99mmHg). 2.Volunteers being able to make self-judgment to participate in this study and giving written informed consent. 3.Volunteers having screening test results judged to be appropriate for this study by investigator.

Exclusion criteria

Exclusion criteria: 1.Patients receiving treatment of hypertension. 2.SBP 160mmHg < ; DBP 100mmHg <. 3.Volunteers having severe history of the diseases (liver, kidney, heart, blood) judged to be inappropriate for this study. 4.Volunteers received gastrectomy, enterectomy, and gastro-intestinal dedeases, judged to be inappropriate for this study. 5.Volunteers rejected participating in this study by chief investigater.

Design outcomes

Primary

Measure	Time frame
Chronological changes and comparison in blood pressure and flow mediated dilation levels among three different doses,(350ml/day extracted from 0, 4, 8g of the dried leaves, respectively).	—

Secondary

Measure	Time frame
Evaluation of the optimum dose amount of persimmon leaf tea intake for the improvement.	—

Countries

Japan

Contacts

Public ContactNiigata Bio-Research Park, Inc

Niigata Bio-Research Park, Inc Business promotion division

goto@nbrp.co.jp0250-25-1196

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026