Unresectable locally advanced pancreatic cancer
Conditions
Interventions
Irreversible Electroporation (IRE)
Sponsors
Tokyo Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. It does not matter whether the pre-treatment but it is necessary that 4 weeks was passed from the pre- treatment 2. It has been confirmed pathologically is adenocarcinoma or adenosquamous carcinoma 3. Patient of unresectable locally advanced pancreatic cancer (no distant metastasis, impossible reconstruction of PV/SMV obstruction, more than 180 degrees SMA/CeA invasion, Ao invasion) 4. Major organs (heart, lung, kidney, liver, etc.) function are maintained a Child-Pugh class A or B b WBC > 2000/L c Platelet count > 50000/l d Prothrombin time > 50% e Cr<3.0mg/dl f Total bilirubin level < 3mg/dl g Cardiac function is normal 5. ECOG score 0 or 1 6. Life expectancy of at least 4 weeks 7. Written informed consent
Exclusion criteria
Exclusion criteria: 1. distant metastasis, 2. CT or MRI contrast agent allergy, 3. Another organs malignancy, 4. Pregnant women or women of childbearing potential not using an acceptable method of contraception, 5. Uncontrolled infection 6. Heart failure, coronary artery disease or arrhythmia in progress, active implantable devices (eg pacemaker) 7 Patient's disability to stop anticoagulant and anti platelet therapy 8. Attending physician determines that inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness of IRE for treatmetn of unresectable locally advanced pancreatic cancer according to local control rate using CT or MRI performed 6 months after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and kind of adverse events of up to 1 month after treatment | — |
Countries
Japan
Contacts
Public ContactAkihiko Tsuchida
Tokyo Medical University Gastrointestinal and pediatric surgery
Outcome results
None listed