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Randomized comparative study for efficacy of esomeprazole and lansoprazole in the prevention of recurrent gastroduodenal ulcer in patients continuously treated with non-steroidal anti-inflammatory drugs

Randomized comparative study for efficacy of esomeprazole and lansoprazole in the prevention of recurrent gastroduodenal ulcer in patients continuously treated with non-steroidal anti-inflammatory drugs - EPZvsLPZ study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000016410
Enrollment
260
Registered
2015-02-02
Start date
2015-02-02
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroduodenal ulcer

Interventions

Esomeprazole 20mg once a day for 12 months Lansoprazole 15mg once a day for 12 months

Sponsors

National Hospital Organization
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) patients with endoscopic diagnosed as gastroduodenal ulcer scar, and continuously treated with non-steroidal anti-inflammatory drugs 2) patients accepted to registration for this study 3) patients with informed consent

Exclusion criteria

Exclusion criteria: 1) Patients with severe heart disease, acute cerebrovascular disease, hematological disease, severe liver disease, severe renal disease, or malignancy. 2) Pregnant women 3) Patients treated with Reyataz or Edulant 4) Patients with allergy for proton pump inhibitor 5) Patients with active gastroduodenal ulcers on the first time of this study 6) Patients with operative history of esophagus or stomach 7) Patients treated with steroids 8) Patients with alcoholism or drug dependence 9) Patients judged as unsuitable by investigator

Design outcomes

Primary

MeasureTime frame
Non-recurrent rate of gastroduodenal ulcer

Countries

Japan

Contacts

Public ContactNaohiko Harada

National Hospital Organization Kyushu Medical Center Department of Gastroenterology

haradan@kyumed.jp092-852-0700

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026