The Nationwide Cancer Genome Screening Projects for Gastrointestinal Cancer in Japan, Efficient Identification of Actionable Cancer Genome Alterations in Advanced Non-Colorectal Gastrointestinal Cancer (SCRUM-Japan GI Screen 2015-01-Non-CRC)

Conditions

Gastrointestinal cancer

Chigusa Morizane, Yoshito Komatsu, Hideaki Takahashi, Makoto Ueno, J. Furuse et al. (20 authors)

Annals of Oncology2018-10-014 citations

The nationwide cancer genome screening project in Japan, SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced esophageal cancer

Ken Kato, Takashi Kojima, H. Saeki, Hiroki Hara, T. Kajiwara et al. (20 authors)

Annals of Oncology2018-10-012 citations

10.1093/annonc/mdy282.011

The nationwide cancer genome screening project in Japan SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced gastric cancer (GC).

Satoshi Yuki, Kohei Shitara, Shigenori Kadowaki, Keiko Minashi, Atsushi Takeno et al. (20 authors)

Journal of Clinical Oncology2018-05-2013 citations

10.1200/jco.2018.36.15_suppl.4050

The Nationwide Cancer Genome Screening Project in Japan, SCRUM-Japan GI-screen: Efficient identification of cancer genome alterations in advanced esophageal cancer.

Yuichiro Nakashima, Takashi Kojima, Hiroki Hara, Ken Kato, Takeshi Kajiwara et al. (20 authors)

Journal of Clinical Oncology2017-05-201 citations

10.1200/jco.2017.35.15_suppl.4062

The Nationwide Cancer Genome Screening Project in Japan SCRUM-Japan, GI-screen: Efficient identification of cancer genome alterations in advanced gastric cancer.

Shigenori Kadowaki, Kohei Shitara, Satoshi Yuki, Shuichi Hironaka, Takeshi Kato et al. (20 authors)

Journal of Clinical Oncology2017-05-201 citations

10.1200/jco.2017.35.15_suppl.4041

The Nationwide Cancer Genome Screening Project in Japan SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced non-colorectal (Non-CRC) gastrointestinal cancer.

Atsuo Takashima, Wataru Okamoto, Shuichi Hironaka, Takeshi Kato, Yoshito Komatsu et al. (19 authors)

Journal of Clinical Oncology2016-05-20

10.1200/jco.2016.34.15_suppl.4058

The Nationwide Cancer Genome Screening Projects for Gastrointestinal Cancer in Japan (SCRUM-Japan GI-SCREEN): Efficient identification of actionable cancer genome alterations in advanced colorectal and non-colorectal gastrointestinal cancer (GI Screen 2013-01-CRC and 2015-01-Non CRC).

Kohei Shitara, Miki Izumi, T. Sudo, Satoshi Fujii, Takeshi Kuwata et al. (20 authors)

Journal of Clinical Oncology2015-05-203 citations

10.1200/jco.2015.33.15_suppl.tps4134

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with histologically confirmed or clinically suspected advanced cancer of following descriptions; 1.gastric or gastro-esophageal junction adenocarcinoma 2.Esophageal cancer(adenocarcinoma or squamous cell carcinoma) 3.Others (adenocarcinoma of small intestine, appendiceal adenocarcinoma, anal cancer, neuroendocrine carcinoma which includes mixed type with adenocarcinoma) 2) Planned to receive systemic chemotherapy for advanced disease 3) Presence or ability to acquire sufficient DNA for target sequencing 4) Written informed consent was obtained

Exclusion criteria

Exclusion criteria: 1) Patient is judged by the investigator to be inappropriate for study participation for any reason.

Design outcomes

Primary

Measure	Time frame
Frequency or characteristics of cancer genome alteration	—

Secondary

Measure	Time frame
Association between each cancer genome alterations and clinicopathological characteristics or prognosis,Quality of the specimen contributing to gene analysis	—

Countries

Japan

Contacts

Public ContactKohei Shitara

National Cancer Center Hospital East Gastrointestinal Oncology Division

kshitara@east.ncc.go.jp04-7133-1111

Outcome results