non-small cell lung cancer
Conditions
Interventions
loperamide,minocyclin,minocycline hydrochloride,azulene sodium sulfonate
Sponsors
Niigata Lung Cancer Treatment Group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Non-small cell lung cancer proven by histology and/or cytology 2.EGFR mutation status is positive 3.Performance Status(ECOG)0-2 4.Afatinib has not been administered in the past 5.Chest radiation therapy that has not been enforced within the registration before 4 weeks 6.Adequate organ function 7.20 years or older 8.Written Informed Consent
Exclusion criteria
Exclusion criteria: (1)History of active double cancer (2)No intention to birth control (3)Unstable psychic disorder (4)Interstitial pneumonia or active radiation pneumonia or drug-induced pneumonia (5)Ileus (6)Patients who can not take oral drugs (7)Severe complications (8)Patients in drug and tetracycline drug used in the present study a history of hypersensitivity (9)Decision of ineligibility by a physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In 4 weeks time Severe diarrhea expression inhibition rate (Severe diarrhea:Diarrhea that is deemed necessary dose reduction of Afatinib dose reduction criteria defined in the protocol | — |
Countries
Japan
Contacts
Public ContactMasaaki Okajima
Niigata University Medical & Dental Hospital Respiratory and infectious diseases internal medicine
Outcome results
None listed