Exercise Stress Echocardiography Compared with Fractional Flow Reserve for the Detection of Significant Coronary Stenosis: Using Multilayer Strain

Exercise Stress Echocardiography Compared with Fractional Flow Reserve for the Detection of Significant Coronary Stenosis: Using Multilayer Strain - Exercise Stress Echocardiography Versus Fractional Flow Reserve

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000016059

Enrollment

Registered

2014-12-26

Start date

2014-12-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease

Interventions

Exercise echocardiography and fractional flow reserve measurement

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who will undergo a coronary angiography or a percutaneous coronary intervention with coronary artery disease, defined as greater than or equal to 50% diameter stenosis by visual estimation, in one or more major epicardial coronary arteries 2. Twenty years of age and older 3. Able to provide informed, written consent

Exclusion criteria

Exclusion criteria: 1. Patients with lesions localized on right coronary ostia or left main coronary artery 2. Atrial fibrillation 3. Recent myocardial infarction (within 7 days) 4. Severe valvular heart disease 5. Decompensated heart failure 6. Advanced renal failure (estimated glomerular filtration rate less than or equal to 30 ml/min) 7. Severe left ventricular dysfunction (ejection fraction less than or equal to 30%) 8. Patients who cannot peddle an ergometer for any reason 9. Pregnant 10. Contraindication to both adenosine triphosphate and papaverine. 11. Patients judged as inappropriate for trial entry

Design outcomes

Primary

Measure	Time frame
The rate of change of endocardial longitudinal strain at rest and after exercise in the myocardial territories supplied by coronary vessels with or without fractional flow reserve less than or eual to 0.80	—

Secondary

Measure	Time frame
Comparison of following parameters assessed by two dimensional or three dimensional speckle tracking echocardiography in the myocardial territories supplied by coronary vessels with or without fractional flow reserve < or = 0.80 (or < 0.75): Endocardial, epicardial, all-layer longitudinal strain, Circumferential strain Radial strain Post systolic index Time to peak strain Time to peak strain index Time from AVC to peak strain Comparison of global longitudinal strain with BNP ECG changes during ecercise echocardiography	—

Measure

Time frame

Comparison of following parameters assessed by two dimensional or three dimensional speckle tracking echocardiography in the myocardial territories supplied by coronary vessels with or without fractional flow reserve < or = 0.80 (or < 0.75): Endocardial, epicardial, all-layer longitudinal strain, Circumferential strain Radial strain Post systolic index Time to peak strain Time to peak strain index Time from AVC to peak strain Comparison of global longitudinal strain with BNP ECG changes during ecercise echocardiography

—

Countries

Japan

Contacts

Public ContactTakeshi Nishi

Chiba university hospital Department of Cardiovascular Medicine

tnishi@chiba-u.jp043-226-2340

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026