Radioiodine Therapy Associated Exacerbation of Initially Inactive or Absent Graves' Ophthalmopathy: A Prospective Study in the Japanese Population: Is Low Dose Prednisolone Effective for Prevention?

Radioiodine Therapy Associated Exacerbation of Initially Inactive or Absent Graves' Ophthalmopathy: A Prospective Study in the Japanese Population: Is Low Dose Prednisolone Effective for Prevention? - Graves' Ophthalmopathy After Radioiodine Therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000016040

Enrollment

133

Registered

2014-12-25

Start date

2011-06-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graves&#39

Interventions

Intervention:Graves&#39

disease with steroid prophylaxis for 6 weeks.In the PSL-On group, patients were initially given 15 mg per day of PSL, with the daily dose then reduced by 5 mg every 2 weeks for a cumulative 420 mg dos

disease without steroid prophylaxis.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Graves' disease with inactive or without GO

Exclusion criteria

Exclusion criteria: 1) active GO and/ or a past history of treatment for GO 2) concomitant disease: diabetes mellitus, gastric ulcer, glaucoma, heart failure, hepatitis C, old age, and steroid treatment for other disease

Design outcomes

Primary

Measure	Time frame
Outcomes of GO 1 year after RIT	—

Countries

Japan

Contacts

Public ContactNatsuko Watanabe

Ito Hospital Internal medicine

n-watanabe@ito-hospital.jp03-3402-7411

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

Radioiodine Therapy Associated Exacerbation of Initially Inactive or Absent Graves&#39; Ophthalmopathy: A Prospective Study in the Japanese Population: Is Low Dose Prednisolone Effective for Prevention?