benign prostate hyperplasia
Conditions
Interventions
Measurement of blood flow to the urinary bladder (healthy young man (20'
s and 30'
s) , patients without benign prostate hyperplasia (45 years or older), before and after 12 weeks of tadalafil therapy in patients with lower urinary tract symptoms secondary to benign prostate hyperpl
Sponsors
Department of Urology, Kyorin University School of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. male patients aged 45 or older 2. patients with lower urinary tract symptoms (IPSS: 8 points or more) 3. patients with prostate volume 20mL or more 4. patients with informed consent
Exclusion criteria
Exclusion criteria: 1. patients with overactive bladder symptoms (OABSS: Q3 2points or more and total score 3 points or more) 2. patients who developed urinary retention in the past 12 months 3. patients strongly suspected of prostate cancer 4. patients with indwelling urethral catheter or intermittent self-catheterization 5. patients with acute urinary tract infection 6. patients with mechanical abnormality of lower urinary tract (eg. urethral stricture, bladder tumor and bladder stone) 7. patients without desire to void 8. patients with uncontrolled hypertension 9. patients with severe heart disease, renal dysfunction or liver dysfunction 10. patients tadalafil is contraindicated 11. patients who have been determined to be unsuitable as a subject by a physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Difference in resistance index of the artery flowing into the bladder between the patients with benign prostate hyperplasia and control 2. Change in resistance index of the artery flowing into the bladder after treatment with tadalafil in patients with benign prostate hyperplasia | — |
Countries
Japan
Contacts
Public ContactMitsuhiro Tambo
Kyorin University School of Medicine Department of Urology
Outcome results
None listed