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The efficacy and safety of a bisoprolol transdermal patch in patients with cerebral hemorrhage

The efficacy and safety of a bisoprolol transdermal patch in patients with cerebral hemorrhage - The efficacy and safety of a bisoprolol transdermal patch in patients with cerebral hemorrhage

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000016023
Enrollment
100
Registered
2015-01-01
Start date
2015-01-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral hemorrhage

Interventions

monotherapy group:constant infusion of nicardipine combination group: bisoprolol transdermal patch(8mg) + constant infusion of nicardipine

Sponsors

Hiratsuka Kyosai Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.patients with cerebral hemorrhage detected by X-ray CT scan 2.patients which need the depressor therapy 3.both new-onset or recurrent cerebral hemorrhage are permitted 4.having prehospital oral medicine or not does not matter 5.no criteria of age

Exclusion criteria

Exclusion criteria: 1.patients of an immediate operation is needed 2.patients with a severe bradycardia or tachycardia 3.patients with atrioventricular block(second-degree or third-degree) or sinoatrial block or sick sinus syndrome 4.patients with severe peripheral circulation disturbance 5.patients with untreated pheochromocytoma 6.pregnant or possibly pregnant 7.patients with a history allergy against nicardipine or bisoprolol 8.patients who are judged inappropriate for the study by the investigators

Design outcomes

Primary

MeasureTime frame
heart rate

Secondary

MeasureTime frame
dose of nicardipine withdrawal of bisoprolol and nicardipine neurological prognosis

Countries

Japan

Contacts

Public ContactRyoo Yamamoto

Hiratsuka Kyosai Hospital Department of Neurology

ryamamoto-tuk@umin.ac.jp0463-32-1950

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026