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Effectiveness of Landiolol for elderly patients at high risk of a cardiovascular event who undergo laparoscopic gastrecomy which potentially induces low cardiac function and tachycardia

Effectiveness of Landiolol for elderly patients at high risk of a cardiovascular event who undergo laparoscopic gastrecomy which potentially induces low cardiac function and tachycardia - Effectiveness of Landiolol in perioperative management of laparoscopic gastrectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000015993
Enrollment
160
Registered
2015-01-01
Start date
2015-01-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General anesthesia, pneumoperitoneum under gastrectomy

Interventions

Landiolol groups: surgery to perform continuously administered intravenously at a safe administration rate 1mcg/kg/min obtained from the results of pilot study on the dose of landiolol. Postoperativel

Sponsors

Fujita Health University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1, It does not matter the gender at 65 years of age or elder. 2, Patients in the evaluation of using the two or more preoperative Revised Cardiac Risk Index(RCRI)

Exclusion criteria

Exclusion criteria: 1. Patients contraindicated of landiolol. (Patients with cardiogenic shock, patients with diabetic acidosis, atrioventricular block II degrees or more), bradyarrhythmia patients such as sick sinus syndrome, patients with pulmonary hypertension and right heart failure, patients with congestive heart failure, patients with untreated pheochromocytoma, and patients with a history of hypersensitivity to landiolol) 2. Patients with emergency surgery 3. Patients with heart rate of 40 times/min or less 4. patients with low blood pressure (systolic blood pressure less than 80mmHg) 5. Patients with severe heart failure (NYHA classification III,IV) 6.Patients assessed by anesthetist preoperative patients participating in the study are determined to be unsuitable

Design outcomes

Primary

MeasureTime frame
The incidence of supra ventricular arrhythmia in 72 hours from the start of administration

Countries

Japan

Contacts

Public ContactKoichi Suda

Fujita Health University Division of Upper GI, Department of Surgery

ko-suda@nifty.com0562-93-9254

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026