Feasibility of Computed Tomography Derived Myocardial Blood Flow Using Whole-Heart Dynamic Computed Tomography Perfusion Imaging: Differentiation of Myocardial Ischemia and Infarction Assessed by Comparison with Cardiac Magnetic Resonance and Single Photon Emission Computed Tomography

Feasibility of Computed Tomography Derived Myocardial Blood Flow Using Whole-Heart Dynamic Computed Tomography Perfusion Imaging: Differentiation of Myocardial Ischemia and Infarction Assessed by Comparison with Cardiac Magnetic Resonance and Single Photon Emission Computed Tomography - Feasibility of CT-MBF for distinguishing among normal, ischemic and infarcted myocardium

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000015964

Enrollment

Registered

2014-12-17

Start date

2010-05-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients who give a full consent to this study (2) Effort or resting angina (chest pain, documented ST-T change on electrocardiogram [ECG], or symptoms relieved by administration of nitroglycerin) (3) Asymptomatic patients with multiple coronary risk factors for CAD. (4) All patients perform ATP-stree dynamic myocardial CT perfusion and myocardial perfusion imaging (SPECT or cardiac MRI) within a month.

Exclusion criteria

Exclusion criteria: (1) acute myocardial infarction (2) cardiomyopathy (3) severe left ventricular dysfunction (ejection fraction < 20%) (4) chronic atrial fibrillation (5) greater than first degree atrio-ventricular block (6) symptomatic congestive heart failure of New York Heart Association class IV (7)percutaneous coronary intervention (8) history of coronary artery bypass graft (9) hypotension (systolic blood pressure < 90 mm Hg) (10) severe chronic obstructive pulmonary disease (11) chronic kidney disease (serum creatinine > 1.5 mg/dl) (12) pregnancy (13) known history of hyperthyroidism and bronchial asthma (14) known hypersensitivity to contrast media.

Design outcomes

Primary

Measure	Time frame
Differentiation of CT-derived MBF among normal, ischemic and infarcted myocardium in patient groups of SPECT and cardiac MR, respectively. Diagnostic accuracy of CT-derived MBF for detecting myocardial perfusion abnormality on SPECT and cardiac MR.	—

Countries

Japan

Contacts

Public ContactYuki Tanabe

Ehime University Graduate School of Medicine. Department of Radiology

yuki.tanabe.0225@gmail.com089-960-5371

Outcome results