Improvement of cognitive function
Conditions
Interventions
Intake 10g of quercetin -rich onion powder (50mg quercetin) daily for 24 weeks.
Intake 10g of White onion powder (0mg quercetin) daily for 24 weeks.
Sponsors
Hokkaido Information University
(1)National Food Research Institute, National Agriculture and Food Research Organization (2)Tokushima University (3)Gifu University (4)National Agriculture and Food Research Organization for Hokkaido Region (5)National Agriculture and Food Research Organization for Tohoku Region (6)Gifu farming techniques center (7)Kagoshima agriculture development synthesis center (8)Okamoto Plant Breeding Co.Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Subjects who show low score of Cognitive impairment rating scale (2)Subjects who agree to participate in the current study with written informed consent. (3) Subject with an study partner.
Exclusion criteria
Exclusion criteria: (1)Subjects who are under medication for dementia, Alzheimer's disease, psychiatric disorder and cerebrovascular disease. (2) Subjects with receiving hormone therapy. (3) Subjects with a history of psychiatric disorder and cerebrovascular disease. (4) Subjects with serious diseases and infections. (5) Subjects with clinical history of gastrointestinal surgery. (6)Subjects with unusually high and/or low blood pressure, or with abnormal hematological data. (7) Subjects with serious anemia. (8)Subjects with a history of allergy to medicine and food, especially onion. (9) Subjects routinely on supplementation which would affect cognitive function. (10) Heavy smokers and alcohol addicts, or subjects with irregular lifestyle. (11) Subjects who donate 400ml whole blood within 12 weeks or who donate plasma or platelets within 4 weeks prior to supplementation. (12) Subjects who are pregnant or under lactation, or ones who would be expected to be pregnant during the study. (13) Subjects who participate in other clinical trials within the last one month prior to the current clinical trial. (14) Subjects who are not eligible due to physician's judgment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini mental state test, Cognitive impairment rating scale | — |
Secondary
| Measure | Time frame |
|---|---|
| blood glucose, HbA1c, T-Cho, LDL-Cho, HDL-Cho, TG, oxo-LDL, estradiol, NPI-Q-J | — |
Countries
Japan
Contacts
Public ContactDir. Prof. Jun Nishihira, M.D.
Hokkaido Information University Health Information Science Center
Outcome results
None listed