The analysis of the host genetic and viral pathological factors causing severe Enterovirus infection

The analysis of the host genetic and viral pathological factors causing severe Enterovirus infection - The host genetic and viral factors related to Enterovirus infection

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000015864

Enrollment

400

Registered

2014-12-05

Start date

2015-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hand, foot, and mouth disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Severe HFMD cases: 1. Clinically diagnosed as HFMD grade II, III, or IV 2. The children requiring hospitalization. (2) Mild HFMD cases: 1. Clinically diagnosed as HFMD grade I 2. The children NOT requiring hospitalization

Exclusion criteria

Exclusion criteria: The children whose family/guardian decline to participate to the study

Design outcomes

Primary

Measure	Time frame
The full genome and amino acids sequence of the isolated EV71 strains	—

Secondary

Measure	Time frame
1) The virological characteristics of the isolated EV71 strains 2) The demographics of the participants 3) The levels of cytokines and catecholamine among EV71 infected individuals 4) The type of HLA-A allele among EV71-infected individuals 5) SNPs of host genome	—

Countries

Asia(except Japan)

Contacts

Public ContactHiroshi ICHIMURA

Graduate school of Medical Sciences, Kanazawa University Department of Viral infection and International Health

ichimura@med.kanazawa-u.ac.jp076-265-2229

Outcome results