The analysis of mucosal immune responses induced by intranasal administration of an inactivated influenza virus vaccine in human (V)

The analysis of mucosal immune responses induced by intranasal administration of an inactivated influenza virus vaccine in human (V) - Comparison of the adaptive immune responses induced by a subcutaneous annual influenza vaccine with those induced by an intranasal vaccination using inactivated whole-virus vaccines.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015851

Enrollment

Registered

2014-12-06

Start date

2014-12-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Influenza

Interventions

Subcutaneous administration of an influenza HA vaccine (split product, each 15 ug HA/dose) is performed once. Intranasal administration of an inactivated whole-virus vaccine (each 45 ug HA/dose) with

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy volunteers who are interested in the open recruitment for our study, and agree with our study contents, as confirmed by giving their informed consent before the onset of the study.

Exclusion criteria

Exclusion criteria: 1. Volunteers with a fever at the time of planned vaccination. 2. Volunteers with serious acute diseases. 3. Volunteers considered inappropriate to be inoculated vaccine.

Design outcomes

Primary

Measure	Time frame
Neutralization, HI, and HA-specific antibody titers before and after intranasal vaccination.	—

Secondary

Measure	Time frame
1. Survey on side reaction after vaccination. 2. The proportion of plasma cell in peripheral blood and the repertoire of antibodies induced by vaccination. 3. Cytokine profile after vaccinaton.	—

Countries

Japan

Contacts

Public ContactHideki Hasegawa

National Institute of Infectious Diseases Department of Pathology

hasegawa@nih.go.jp+81-3-5285-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026