Phase I/II study of S-1, docetaxel, oxaliplatin combination chemotherapy (DOS) in patients with HER2-negative unresectable metastatic gastric cancer

Phase I/II study of S-1, docetaxel, oxaliplatin combination chemotherapy (DOS) in patients with HER2-negative unresectable metastatic gastric cancer - Phase I/II study of S-1, docetaxel, oxaliplatin combination chemotherapy (DOS) in patients with HER2-negative unresectable metastatic gastric cancer

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015849

Enrollment

Registered

2014-12-04

Start date

2014-12-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastric cancer

Interventions

Treatment with docetaxel (50mg/m2), Oxaliplatin (80-130 mg/m2), S-1 (80mg/m2) combination chemotherapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Written informed consent. 2)Histologicaly (cytologically) proven gastric cancer. 3)HER2 negative method 4)Unresectable gastric cancer. 5)To have evaluable lesions. 6)No prior chemotherapy or no influence of prior therapy. 7)Tolerable function of bone marrow, liver and kidney. 8)PS 0 - 1. 9)Expected survival for 3 months. 10)Possible oral intake.

Exclusion criteria

Exclusion criteria: 1)History of hypersensitivity to DCS. 2)Contraindication to Oxaliplatin, CDDP, S-1, G-CSF. 3)Infectious disease. 4)Severe compliaction. 5)Neuropathy greater than grade 2. 6)Brain metastasis with clinical symptoms. 7)Watery diarea. 8)Active double cancer. 9)Persons to be pregnant or to make pregnant.

Design outcomes

Primary

Measure	Time frame
Incidence of dose limiting toxicity Response rate	—

Countries

Japan

Contacts

Public ContactYasushi Sato

Tokushima University Graduate School of Biomedical Sciences Department of Community Medicine for Gastroenterology and Oncology

sato.yasushi@tokushima-u.ac.jp088-633-7124

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026