The cough mechanisms due to gastroesophageal reflux disease: relationship between expression of acid and mechanical stress receptor in esophageal mucosa and neurogenic inflammation

The cough mechanisms due to gastroesophageal reflux disease: relationship between expression of acid and mechanical stress receptor in esophageal mucosa and neurogenic inflammation - The cough mechanisms due to gastroesophageal reflux disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000015828

Enrollment

Registered

2014-12-15

Start date

2015-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastroesophageal reflux-associated chronic cough

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Chronic cough group Patients with persistent cough for 8 weeks or longer and concomitantly having GERD symptom. 2) Control group Patients with GERD but without cough symptom

Exclusion criteria

Exclusion criteria: 1)patients recieved oral or systemic steroid within one month. 2)patients recieved proton-pomp inhibitor and histamine H2 receptor antagonist within one month. 3)patients having angiotensin converting enzyme inhibitor, anti-leukotriene receptor antagonist and histamine H1 receptor antagonist. 4)patients who are pregnant or possibly pregnant. 5)Patients who are inappropriate to enter this study judged by the physician.

Design outcomes

Primary

Measure	Time frame
Expression level of TRPV1, TRPV4 and ENAC in esophageal mucosa	—

Secondary

Measure	Time frame
1)Expression level of SP and CGRP in esophageal mucosa. 2)relationship between expression level of TRPV1, TRPV4, ENAC, SP and CGRP and clinical indicators.	—

Countries

Japan

Contacts

Public ContactNorihisa Takeda

Graduate School of Medical Sciences, Nagoya City University Respiratory Medicine, Allergy and Clinical Immunology

nori-take-ncu@hotmail.co.jp052-853-8216

Outcome results