Normal subjects and patients with brain tumors
Conditions
Interventions
Additional performance of QSM, ASL and DCE to conventional MRI
Sponsors
Hokkaido University Hospital
Hitach, Ltd. Hitach Medical Corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Healthy volunteers 1.Healthy male and female (20 - 60 years old) 2.Informed consent is obtained (2)Patients with brain tumors 1.Adult 2.Brain tumors with diameter of no less than 1cm shown in enhanced MRI 3.FMISO-PET performed at our institute 4.Preserved major organ functions 5.Metastatic brain tumors histopathologically diagnosed by extracranial lesions 6.Informed consent is obtained
Exclusion criteria
Exclusion criteria: 1.Metallic implant or device not applicable to MRI 2.Unable to be at rest on his/her back or claustrophobia 3.Pregnant 4.Other inadequate cases 5.Allergic to gadlinium agents 6.Renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Step 1-2 Correlation between StO2 values of lower extremity calculated by QSM and percutaneously measured by pulse oxymeter. Step 2 (1)Correlation between StO2 value calculated by QSM and 18F-FMISO accumulation (2)Comparison between distributions of hypoxic areas illustrated by QSM and FMISO-PET | — |
Secondary
| Measure | Time frame |
|---|---|
| Step 1-2 Correration between StO2 value of lower extremity calculated by QSM and applied pressure Step 2 (1)Correlations between MRI findings in ASL/DCE and 18F-FMISO accumulation (2)Relation between results in radiation therapy and MR findings before radiation, change in MR findings between pre and post radiation (3)Relation between histopathology and MR findings in metastatic brain tumors | — |
Countries
Japan
Contacts
Public ContactYukie Shimizu
Hokkaido University Hospital Department of Diagnostic and Interventional Radiology
Outcome results
None listed