Effect of ONO-8539 on acid-induced heartburn symptom in healthy volunteers

Effect of ONO-8539 on acid-induced heartburn symptom in healthy volunteers - Effect of ONO-8539 on heartburn

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015753

Enrollment

Registered

2014-11-25

Start date

2014-11-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal Reflux Disease (GERD)

Interventions

ONO-8539 Placebo

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Healthy male subjects 2. Sufficient informed consent is obtained

Exclusion criteria

Exclusion criteria: 1. Subjects who undergo upper gastrointestinal endoscopy and are found to have significant organic diseases (e.g., esophagitis, Barrett's esophagus, hiatus hernia, active peptic ulcer disease, and esophageal/gastric cancer) 2. Subjects with history of peptic ulcer or upper GI tract surgery 3. Subjects with significant cardiovascular, kidney, liver, neurotic, or psychological disorders 4. Subjects diagnosed with GERD by questionnaire 5. Subjects taking medications that may affect prostaglandin generation, including NSAIDs, COX-2 inhibitors, or prostaglandin-containing medications 6. Individuals judged by investigators as ineligible for study enrollment

Design outcomes

Primary

Measure	Time frame
Change in heartburn symptom score during acid perfusion test	—

Countries

Japan

Contacts

Public ContactTakashi Kondo

Hyogo College of Medicine Department of Internal Medicine Division of Gastroenterology

kondou@hyo-med.ac.jp0798-45-6662

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026