type 2 diabetes mellitus
Conditions
Interventions
Patients with type 2 diabetes mellitus undergo a meal tolerance test to examine changes in postprandial endothelial function and changes in glucose and lipid metabolism without exenatide administratio
Sponsors
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) age 20 to less than 80; 2) no change in oral antihyperglycemic drug therapy, lipid metabolism-improving drug therapy, or antihypertensive drug therapy during the 12 weeks preceding enrollment; and 3) ongoing treatment by diet regimen alone or by therapy with sulfonylurea, sulfonylurea plus biguanide, or sulfonylurea plus thiazolidine derivatives.
Exclusion criteria
Exclusion criteria: 1) receiving insulin therapy; 2) having diabetic ketoacidosis, nonketotic hyperosmolar coma, infection, or acute coronary syndrome; 3) being pregnant or possibly pregnant; 4) having a history of stroke or ischemic heart disease occurring within the preceding 6 months; 5) having a history of pancreatitis; and 6) having arrhythmia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the difference between changes in postprandial vascular endothelial function without eventide administration compared with single-dose exenatide administration. | — |
Countries
Japan
Contacts
Public ContactKeiichi Torimoto
School of Medicine, University of Occupational and Environmental Health First Department of Internal Medicine
Outcome results
None listed