condition which needs operation under anesthesia
Conditions
Interventions
Perform the intravenous sedation three times on separate days: first without pregabalin, second oral premadication of pregabalin 100mg and third oral pregabalin 200mg taken 1 hour before the intraveno
Sponsors
Faculty of Dental Science, Kyushu University, Department of Dental Anesthesiology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria were without any clinical history, ASA physical status 1, and 20s to 30s male and female. After obtaining the written informed consent, we performed blood examination and electrocardiogram for health check.
Exclusion criteria
Exclusion criteria: Volunteers were excluded from recruitment if they were allergic to egg, soy and milk, allergic to any antibiotics or painkiller, chronic neuralgia patients, taking any GABA derivatives, or had dental disease that might cause severe pain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood concentration of propofol to acheive the sufficient sedative level during intravenous sedation | — |
Secondary
| Measure | Time frame |
|---|---|
| Circulation and respiration dynamics during intravenous sedation, perioperative analgesic effect, first propofol injection-induced pain and side effects at 30 minutes and 1hour after pregabalin administration, and 30 minutes. 1 hour and 5 hour after the intravenous sedation end. | — |
Countries
Japan
Contacts
Public ContactNoriko Karube
Faculty of Dental Science, Kyushu University Department of Dental Anesthesiology
Outcome results
None listed