Efficacy of epidural administration of ant-TNF-alfa and anti-interleukin-6 receptor antibody onto spinal nerve for treatment of sciatica.

Efficacy of epidural administration of ant-TNF-alfa and anti-interleukin-6 receptor antibody onto spinal nerve for treatment of sciatica. - Anti-Cytokine therapy for radicular pain (ACTRP)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015670

Enrollment

Registered

2014-11-12

Start date

2014-11-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

low back and radicular leg pain caused by spinal stenosis were investigated.

Interventions

1% Xylocaine 1% Xylocaine + anti-TNF-alfa receptor antibody 1% Xylocaine + anti-interleukin-6 receptor antibody

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1 Patients with low back pain, leg pain, or intermittent claudication 2 patients with pain that can beexplained X-ray, CT, MRIand discography.

Exclusion criteria

Exclusion criteria: 1 Patients with impaired consciousness 2 Patients with severe heart failure, renal failure, liver failure and systemic complications such as respiratory failure.

Design outcomes

Primary

Measure	Time frame
Pain relief side effect	—

Countries

Japan

Contacts

Public ContactSeiji Ohtori

Graduate School of Medicine, Chiba University Orthopaedic Surgery

sohotri@faculty.chiba-u.jp043-226-2117

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026