angina pectoris, old/subacute myocardial infarction, post operative pain
Conditions
Interventions
Patients are given the study drugs 8 times every 6 hours from 30 minutes before the start of surgery to post operative day 2. Study Drugs Intervention group: intravenous acetaminophen 15mg/kg(1.5ml/
Sponsors
IMS Katsushika Heart Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Ischemic heart disease patients who have off-pump coronary artery bypass grafting surgery.
Exclusion criteria
Exclusion criteria: Fraility scale>=5 Disability of expressing pain Patients of converting the surgery to on-pump coronary artery bypass grafting surgeries Patients using intra-aortic balloon pumping or extracorporeal membrane oxygenation devises The nutritionally-depleted patient: body mass index<18.5 or serum albumin level<3.5g/dl Patients with liver disease: chronic virus hepatitis, alcoholic hepatitis, chronic cirrhosis Preoperative blood abnormal value of AST(aspartate aminotransferase)>=120U/l, ALT(alanine aminotransferase)>=135U/l, total bilirubin>=2.4mg/dl Hemodialysis patients Impaired renal function: serum creatinine level>=3.0mg/dl Patients with aspirin-induced asthma Patients who are taking vitamin K antagonist, isoniazid, carbamazepine, phenobarbital, phenytoin, primidone, rifampicin Patients with the allergy to acetaminophen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain scale at 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45 hours after ICU admission and at the morning of POD3,4,5 and at the discharge: including Behavioral Pain Scale, Visual Analog Scale, Numerical Rating Scale The total amount of morphine consumption for pain reliever The incidence of postoperative nausea and vomiting during ICU stay | — |
Secondary
| Measure | Time frame |
|---|---|
| Intra- and post-operative bleeding volume Postoperative serum AST(aspartate aminotransferase), ALT(alanine aminotransferase), total bilirubin, alkaline phosphatase value Postoperative blood platelet counts, prothrombin time, PT-INR, activated partial thromboplastin time Postoperative renal function: serum creatinine level and the rate of variability against the preoperative value The duration of mechanical ventilation The duration of ICU stay The progress of postoperative rehabilitation by POD3 The incidence of postoperative adverse events | — |
Countries
Japan
Contacts
Public ContactToshihiro Nohmi
IMS Katsushika Heart Center Anesthesiology
Outcome results
None listed