Chronic Obstructive Lung disease
Conditions
Interventions
None listed
Sponsors
Graduate School of Medicine, Kyoto University Department of Respiratory Care and Sleep Control Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Diagnosed as COPD and receives appropriate treatment for COPD (based on Japanese Guideline) 2) Indication for long-term oxygen therapy (LTOT) or NIV (based on Japanese health insurance or NIV guideline) 3) >10 years of smoking history 4) no changes in the treatments for COPD in the previous 4 weeks 5) clinically stable in the previous 4 weeks
Exclusion criteria
Exclusion criteria: 1) pH <7.30 in ABG 2) current smoking 3) strongly suspected for sleep apnea (4%ODI [oxygen desaturation index 4%] >20) 4) chronic use of systemic glucocorticosteroids 5) pneumothorax in the previous 6 months 6) having other chronic pulmonary disease 7) clinically obvious heart failure 8) acute infection or malignancy 9) previous or current use of LTOT or NIV 10) pregnancy or lactation 11) other cases not suitable for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in PaO2 (oxygen group) or PaCO2 (NIV group) before and after the treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Pulmonary function test 2) exercise tolerance (assessed by 6MWT) 3) physical activity (assessed by accelerometer) 4) Health-related QOL 5) Exacerabtions of COPD 6) Mortality | — |
Countries
Japan
Contacts
Public ContactKimihiko Murase
Graduate School of Medicine, Kyoto University Respiratory Medicine
Outcome results
None listed