The clinical trials for pain relief and side effects of anti VEGF therapy for chronic lumbar discogenic low back pain -Part I ,II phase test -

The clinical trials for pain relief and side effects of anti VEGF therapy for chronic lumbar discogenic low back pain -Part I ,II phase test - - Anti-VEGF therapy for discogenic low back pain

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015611

Enrollment

Registered

2015-05-01

Start date

2014-01-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Discogenic low back pain

Interventions

intradiscal administration of local anesthetic agent(bupivacaine)and pegaputanib Na group intradiscal administration of local anesthetic agent (bupivacaine)group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.low back pain,leg pain 2.X-ray and MRI can explain the condition 3.less than 2 disc degeneration 4.Spinal instability 5.agreement with this study 6.refractory to 3 months of conservative treatments

Exclusion criteria

Exclusion criteria: 1.loss of consiousness 2.case with history of spinal surgery, infection 3.severe systemic complications 4.diabetes mellitus 5.psychiatric disease 6.pregnant women and women suspected of being pregnant 7.case with malignancy 8.the case considered to be unsuitable as a subject

Design outcomes

Primary

Measure	Time frame
low back pain visual analog scale(VAS)	—

Countries

Japan

Contacts

Public ContactSato Jun

Graduate School of Medicine, Chiba University Department of Orthopaedic Surgery

scottie6242000@yahoo.co.jp043-226-2117

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026