Study for the prevention of Japanese cedar pollinosis by sublingual immunotherapy with Japanese cedar pollen extract. - A randomized controlled trial for the subjects with positive sensibilization having not symptoms -

Study for the prevention of Japanese cedar pollinosis by sublingual immunotherapy with Japanese cedar pollen extract. - A randomized controlled trial for the subjects with positive sensibilization having not symptoms - - Study for the prevention of Japanese cedar pollinosis by sublingual immunotherapy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015603

Enrollment

180

Registered

2014-11-04

Start date

2014-11-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Japanese cedar pollinosis

Interventions

From December 2014 to Apirl 2015, patients of control 1 receive active treatment everyday. The induction/build-up phase is 2 weeks,with an increasing daliy number of the extract drops at two consentra

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)There is not medical history of cedar pollinosis 2)Positive specific IgE to cry j1/2 antigen(ImmunoCAP>=class2) 3)No affirmation of symotoms by cedar pollen antigen provocation test before entering the examination.

Exclusion criteria

Exclusion criteria: 1)Severe asthma 2)Malignat disease or immmun disorder 3)Severe heart disease, lung deisease and hypertension 4)Using of systemic steroid 5)Perennial allregic rhinitis for which treatment is required 6)Complication of the other nasal-paranasal disease which influence the effect of SLIT 7)Using of drug which influence the effect of SLIT 8)Pregnant women and those at risk of pregnancy 9)lactating woman 10)The patients who the doctor judged inaproppriate for the study

Design outcomes

Primary

Measure	Time frame
Ratio of onset of Japanese cedar pollinosis(1 and 2) 1.Increasing of nasal symptom score in the peak pollen season 2.affirmation of symotoms by cedar pollen antigen provocation test after cedar pollen scattering	—

Secondary

Measure	Time frame
1.Increasing of nasal symptom score in the peak pollen season. 2.Affirmation of symotoms by cedar pollen antigen provocation test after cedar pollen scattering 3.Adherence of sublingual immunotherapy 4.Safty	—

Countries

Japan

Contacts

Public ContactSyuji Yonekura

Chiba University Graduate School Department of Otorhinolaryngology

syonekura@faculty.chiba-u.jp043-222-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026