Research for selecting opioid using biomarker for cancer pain

Research for selecting opioid using biomarker for cancer pain - RELIEF STUDY

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015579

Enrollment

140

Registered

2014-11-04

Start date

2014-11-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Pain

Interventions

morphine COMT GG oxycodone COMT GG morphine COMT Non-GG oxycodone COMT Non-GG

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: First screening registration entry 1 Patients with advanced malignant tumors 2 Opioid non daily use patients Secondary screening registration entry 1 Cancer pain,that is targeted for the opioid treatment,taking NSAIDs or acetaminophen 2 NRS is 3 or more 3 Opioid treatment naive within 30 hours 4 Patients who have no influence on previous chemotherapy, radiation therapy 5 Written informed consent

Exclusion criteria

Exclusion criteria: 1) patients with chronic renal failure (glomerular filtration rate, 30 mL/min), 2) patients with severe hepatic or respiratory failure 3) patients deemed ineligible for the study by the study coordinator or a collaborative investigator

Design outcomes

Primary

Measure	Time frame
The rate of high dose opioid on Day0	—

Countries

Japan

Contacts

Public ContactHiromichi Matsuoka

Kinki University, Faculty of Medicine Palliative Care Center

matsuoka_h@med.kindai.ac.jp072-366-0221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026