Measuring Plasma Orexin Concentrations in Narcolepsy and Idiopathic Hypersomnia

Measuring Plasma Orexin Concentrations in Narcolepsy and Idiopathic Hypersomnia - Measuring Plasma Orexin Concentrations

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015562

Enrollment

100

Registered

2014-11-01

Start date

2014-10-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Narcolepsy &amp

Interventions

Blood samples are taken at 9:00, 11:00, 13:00, 15:00, and 17:00 in order to measure the plasma concentrations of orexin, glucose, insulin, leptin, adiponectin, cortisol, ACTH, progesterone, etc., and

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The narcolepsy group and idiopathic hypersomnia group consist of patients whose symptoms and laboratory findings meet ICSD-2 (the International Classification of Sleep Disorders,2005) diagnostic criteria for narcolepsy and idiopathic hypersomnia respectively.

Exclusion criteria

Exclusion criteria: The control group consists of normal subjects without sleep disorders, mental disorders, the direct physiological effects of a substance (e.g., a sedative, hypnotic, or stimulant, etc.), and severe physical diseases. Patients with anemia or renal failure are excluded from the narcolepsy group, the idiopathic hypersomnia group, and the control group.

Design outcomes

Primary

Measure	Time frame
plasma orexin concentrations	—

Secondary

Measure	Time frame
sleepiness measured with the Multiple Sleep Latency Test (MSLT) Epworth Sleepiness Scale (ESS) Visual Analog Scale (VAS)	—

Countries

Japan

Contacts

Public ContactShigeki Takei

School of Medicine, Keio University Department of Laboratory Medicine

takei.shigeki@jcom.zaq.ne.jp03-3353-1211(ext.62522)

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026