A study of the effectiveness of prophylactic granulocyte colony-stimulating factor (G-CSF) for patients with esophageal cancer who receive DCF therapy.

A study of the effectiveness of prophylactic granulocyte colony-stimulating factor (G-CSF) for patients with esophageal cancer who receive DCF therapy. - A study of the effectiveness of prophylactic G-CSF for patients with esophageal cancer who receive DCF therapy.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015561

Enrollment

Registered

2014-10-30

Start date

2014-10-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal cancer

Interventions

Subcutaneously injection of 50mcg/m&amp

sup2

Filgrastim as G-CSF by the following dose from day 7 to 13 of DCF 1 kur.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Histologically confirmed esophageal cancer. 2.Patients who receive DCF therapy. 3.ECOG PS0-2. 4.Adequate organ function according to following laboratory values obtained within 14 days before enrolement. CCr>=60ml/min T-Bil<=1.5mg/dl AST&ALT<=100IU/l Hb>=8g/dl Plt>=10x10^4/mm3 5.Written informed concent.

Exclusion criteria

Exclusion criteria: 1.G-CSF hypersensitivity. 2.Administration of G-CSF within 6 weeks. 3.Infection within 2 weeks. 4.Past history of chemotherapy or radiation therapy. 5.Patients who are pregnant, lactating, with child-bearing potential. 6.Patients who is judged by the investigator to be inappropriate for study participation for any reason.

Design outcomes

Primary

Measure	Time frame
incidence of febrile neutropenia	—

Secondary

Measure	Time frame
incidence of myelosupression, duration of neutropenia, adverse event	—

Countries

Japan

Contacts

Public ContactMakoto Yamasaki

Osaka University School of Medicine Gastroenterological Surgery

myamasaki@gesurg.med.osaka-u.ac.jp06-6879-3251

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026