Parkinson'
Conditions
Interventions
paroxetine 20mg
Escitalopram 10mg
Duloxetine 40mg
Sponsors
Osaka Redcross Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The patient should be diagnosed with Parkinson's disease whose score of QIDS-J is 6 and more. 2. The agreement of the study from the applicant is needed. 3. The patient should be 40 years and more.
Exclusion criteria
Exclusion criteria: . have a history of drug already . have a medication with MAO-B inhibitor within 2 weeks before entry. . Taking the medication with Pimozide . Prolonged QT syndrome . severe liver dysfuncation . severe renal dysfunction . poorly controlled obstructive glaucoma . have a history of suicide attempt . Psychiatric disease needed for medication within 1 year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The clinical symptoms is evaluated at 6weeks and 10weeks after the drug administration by the following modalities; Primary outcomes 1. Quick Inventory of Depressive Symptomatology: QIDS-J 2. Apathy Score | — |
Secondary
| Measure | Time frame |
|---|---|
| Key secondary outcomes 1. Freezing of Gait Questionnaire:FOG-Q 2. Clinical Global Impression of Severity:CGI-S | — |
Countries
Japan
Contacts
Public ContactMakio Takahashi
Osaka Redcross Hospital, Japan Redcross Neurology
Outcome results
None listed