Esophageal Cancer
Conditions
Interventions
Proton beam therapy concurrently with chemotherapy
Sponsors
National Cancer Center Hospital East
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Histologically proven squamous cell carcinoma or adenosquamous cell carcinoma 2) Primary lesion are located within the thoracic esophagus 3) Clinical stage IB or II or III (non-T4) 4) Aged 20 to 75 years old 5) ECOG PS of 0 or1 6) adequate organ functions 7) no previous treatment of esophageal cancer except EMR or ESD 8) no previous chemotherapy or radiotherapy against any other malignancies 9) written informed consent
Exclusion criteria
Exclusion criteria: 1. Active double cancer 2. Active infection 3. Body temperature is under 38 centigrade 4. Possible pregnancy 5. Severe psychological disease 6. Systemic steroid user 7. Positive HBs antigen 8. Uncontrolled diabetes 9. Uncontrolled hypertension 10. Unstable angina, cardiac infarction within 6 months before enrollment 11. Interstitial pneumonitis, pulmonary fibrosis, severe emphysema, heart failure 12. Cerebrovascular disease within 6 months before enrollment 13. History of iodine allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of dose limiting toxicity | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event, Complete response rate | — |
Countries
Japan
Contacts
Public ContactMasakatsu Onozawa
National Cancer Center Hospital East Radation oncology Division
Outcome results
None listed