Effect of glycemic control using glucose-insulin infusion on postoperative inflammatory responses, renal function, complications, and outcomes in major oral and maxiilfacial surgery

Effect of glycemic control using glucose-insulin infusion on postoperative inflammatory responses, renal function, complications, and outcomes in major oral and maxiilfacial surgery - Effect of glycemic control during oral and maxillofacial surgery on postoperative inflammatory responses and outcome

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015522

Enrollment

Registered

2014-10-25

Start date

2013-01-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who are schduled for radical operation of oral malignant tumors along with tissue reconstruction

Interventions

Regular insulin was continuously applied along with infusion of glucose-containing acetate Ringer&amp

#39

s solution (10g glucose per 500mL) during surgery, and blood glucose wa adjusted within the target concentration of 80 - 120 mg/dL. Acetate Ringer&amp

s solution, which contains 1% (W/V) glucose or lactate Ringer&amp

s solution, which does not contain glucose, was infused, and regular insulin is applied each time when a blood glucose concentration is 180mg/dL or more.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with ASA physical status 1-2 and those who are scheduled for radical operations of oral malignant tumors with tissue reconstruction.

Exclusion criteria

Exclusion criteria: Patients whose operation time is less than 8H or those who were not able to continue insulin infusion due to hypoglycemia.

Design outcomes

Primary

Measure	Time frame
It is supposed that postoperative inflammatory responses, postoperative complications, and days required until discharge may be reduced by intraoperative glucose-insulin infusion.	—

Countries

Japan

Contacts

Public ContactAtsushi Kohjitani

Kagoshima University Medical and Dental Hospital Dental Anesthesiology

atsushik@dent.kagoshima-u.ac.jp099-275-6287

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026