Feasibility study on detecting EGFR T790M mutation in cell free DNA from advanced non small cell lung cancer patients refractory to EGFR-TKI:WJOG8014LTR

Feasibility study on detecting EGFR T790M mutation in cell free DNA from advanced non small cell lung cancer patients refractory to EGFR-TKI:WJOG8014LTR - Feasibility study on detecting EGFR T790M mutation in cell free DNA from advanced non small cell lung cancer patients refractory to EGFR-TKI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000015461

Enrollment

155

Registered

2014-10-17

Start date

2014-11-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced non-small cell lung cancer with EGFR mutation

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) advanced non-small cell lung cancer harboring EGFR mutations 2) refractory to EGFR-TKI monotherapy or combination therapy * accept patients receiving EGFR-TKI therapy beyond PD with or without local therapy such as radiation therapy for brain or bone metastasis 3) written informed consent obtained from the patient

Exclusion criteria

Exclusion criteria: Not applicable

Design outcomes

Primary

Measure	Time frame
feasibility of detecting EGFR T790M mutation in cell free DNA from advanced non small cell lung cancer patients refractory to EGFR-TKI	—

Secondary

Measure	Time frame
detection rate of EGFR T790M mutations in plasma concordance of EGFR mutation status between tissue sample and plasma correlation between EGFR mutation status and clinical background	—

Countries

Japan

Contacts

Public ContactShinichiro Nakamura

West Japan Oncology Group datacenter

datacenter@wjog.jp06-6633-7400

Outcome results