Patients of dementia with behavior and psychological symptoms (BPSD), depression, schizophrenia, developmental disorder and Parkinson'
Conditions
Interventions
Exposure of inaudible sounds
Exposure of sounds without inaudible frequency ranges
Sponsors
National Center of Neurology and Psychiatry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients who meet criteria of major neurocognitive disorders by DSM-5 and have one caregiver (living with the patient at least ten hours a week). 2. Patients who meet criteria of major depresive disorder, schizophrenia, developmental disorder or Parkinson's disease.
Exclusion criteria
Exclusion criteria: 1. In case they show suicide attempt, excitement and violence. 2. In case they have history of developmental disorder, bipolar disorder or alchol/drug abuse. 3. In case they have hearing difficulties. 4. In case they meet a contraindication for MRI scan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlations between the structual characteristics of brain and changes in brain activities induced by inaudible sounds | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlations between the structual and functional characteristics of brain induced by inaudible sounds and the flowing items. 1. Scores of rating scales for neuropsychiatric symptoms, including HAM-D, MADRS, MMSE, BEHAVE-AD, NPI, MINI, BACS-J. 2. Scores of cognitive functions including executive functions (WCST, Uchida-Kraepelin (U-K) test), attention function (CPT, Go/NoGo task), working memory, and emotion recognition (facial expression identification/discrimination). | — |
Countries
Japan
Contacts
Public ContactYuichi Yamashita
National Center of Neurology and Psychiatry Department of Functional Brain Research, National Institute of Neuroscience
Outcome results
None listed