Cartilage defects associated with osteoarthritis of the knee
Conditions
Interventions
Chondrocytes isolated from samples obtained at polydactyly surgery are passaged in culture as allogeneic cells and then cryopreserved. From the cryopreserved samples, cells which have been verified fo
Sponsors
Tokai University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Cartilage defects under arthroscopy must be greater than or equal to Outerbridge classification Grade III. In addition, the patellofemoral joint and/or the condyle of the femur must have a cartilage defect or defects which can be fully covered by allogeneic chondrocyte sheets and which have traditionally been indicated for marrow stimulation techniques or osteochondral autografts.
Exclusion criteria
Exclusion criteria: 1. Obtaining informed consent from the patient is difficult. 2. Having complications hindering surgery under general anesthesia or complications affecting knee surgery. 3. Having problematic infectious disease (including positive of HBV, HCV, HIV, HTLV, FTA-ABS.) 4. Having rheumatoid arthritis or other systemic inflammatory disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency and content of adverse events. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical evaluation, X-ray, MRl, Arthroscopy, Photoacoustic evaluation, and Pathological evaluation. | — |
Countries
Japan
Contacts
Public ContactMasato Sato
Tokai University School of Medicine Surgical Science, Department of Orthopaedic Surgery
Outcome results
None listed