The effect of pre-landiololtreatment on ischemic reperfusion injury in acute myocardial infarction trial

The effect of pre-landiololtreatment on ischemic reperfusion injury in acute myocardial infarction trial - PROTECTION trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015198

Enrollment

Registered

2014-09-17

Start date

2014-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute myocardial infarction

Interventions

Intravenous landiolol injection saline injection

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients with acute myocardial infarction within 12 hours after onset

Exclusion criteria

Exclusion criteria: (a) Killip class III or IV (b) systolic BP less than 120 mmHg (c)PR duration over 240 ms (d)AV block (grade II ro III) (e)heart rate less than 60bpm (f)Patients receiving oral beta blockers (g) LVEF less than 30% (h) Patients having allergy against landiolol and/or nitrates (i)patients receiving any unapproved drugs for clinical study within 6 months (j)Pregnant (k)patients having any disease which is less than 12 months of prognosis (l)Diabetic ketoacidosis or metabolic ketoacidosis (m)Prior myocadial infarction (n)patients wiht pacemaker or ICD

Design outcomes

Primary

Measure	Time frame
Myocardial salvage index determined with MRI	—

Countries

Japan

Contacts

Public ContactToru Miyoshi

Okayama University Cardiovascular Medicine

miyoshit@cc.okayama-u.ac.jp086-235-7351

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026