Chronic Kidney Disease
Conditions
Interventions
Provide guidance of moderate protein-restricted diet. Lanthanum carbonate is administered for 12 months. Dose of lanthanum carbonate is 750-2250 mg/day. Lanthanum carbonate is administered 3 times/da
Sponsors
Daiko-Sunadabashi Clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Chronic Kidney Disease stage G4-G5(GFR<30 ml/min/1.73m2) Patients with hyperphosphatemia and without treatments with phosphate binders Patients taking RAS inhibitor, must have taken the RAS inhibitors more than two months. The patient without a hypersensitivity to lanthanum carbonate in pretreatment,history, and complications. Patients who provided written concent to participate in this study after a sufficient explanation.
Exclusion criteria
Exclusion criteria: Under 20 years old when informed concent Patients who have a contraindication that is shown in the product documents of lanthanum carbonate or calcium carbonate. Pregnant women or women with possibility of pregnancy. Patients who are inadequate by determination of physician in charge
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of FGF23 levels between Moderate protein-restricted diet with lanthanum carbonate versus moderate protein-restricted diet alone | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of serum levels of phosphate, Urinary phosphate excretion, Urinary protein content,eGFR,1/Cr,Cr,and Urinary FGF23 between Moderate protein-restricted diet with lanthanum carbonate versus moderate protein-restricted diet alone | — |
Countries
Japan
Contacts
Public ContactIssei Onji
Daiko-Sunadabashi Clinic Planning and Coordination Office
Outcome results
None listed