Oral malodor
Conditions
Interventions
Single ingestion of lactoferrin and lactoperoxidase-containing food >
Washout period (1 week) Single ingestion of placebo food
Single ingestion of placebo food >
Washout period (1 week) Single ingestion of lactoferrin and lactoperoxidase-containing food
Sponsors
Shimizu dental clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects aged 20-65 years 2) Subjects who have volatile sulfur compounds in mouth air above the olfactory threshold (hydrogen sulfide >1.5 ng and methyl mercaptan >0.5 ng/10 ml air)
Exclusion criteria
Exclusion criteria: 1) Subjects who have severe disease of liver, kidney, heart, lung, gastro-intestine, blood, endocrine system, metabolic system etc. 2) Subjects who are receiving treatment of dental disease such as caries and periodontal disease 3) Subjects who received treatment with antibiotics in the past 1 month 4) Subjects who participated in other clinical studies in the past 1 month 5) Subjects with a history of allergy to milk or dairy products 6) Subjects who are pregnant or under lactation, or ones who would be expected to be pregnant during the study 7) Subjects judged inappropriate for the study by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of volatile sulfur compounds in oral air | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentrations of hydrogen sulfide and methyl mercaptan in oral air | — |
Countries
Japan
Contacts
Public ContactEiju Shimizu
Shimizu dental clinic Dentistry
Outcome results
None listed