A prospective observational study of evaluating of the effect of denosumab on bone mineral density and biochemical markers of bone turnover in postmenopausal type 2 diabetes women with low bone mass who are intractable to treatment of bisphosphonate or selective estrogen receptor modulator

A prospective observational study of evaluating of the effect of denosumab on bone mineral density and biochemical markers of bone turnover in postmenopausal type 2 diabetes women with low bone mass who are intractable to treatment of bisphosphonate or selective estrogen receptor modulator - A prospective observational study of evaluating of the effect of denosumab on BMD and biochemical markers of bone turnover in postmenopausal T2D women with low bone mass who are intractable to treatment of bisphosphonate or SERM

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000015136

Enrollment

Registered

2014-09-11

Start date

2014-09-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus, Osteoporosis

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Subjects were postmenopausal women with T2D whose YAM is less than 80% at femoral neck or lumbar spine by dual-energy X-ray absorptiometry in spite of having treatments of active type Vit.D and bisphosphonate or SERM for more than six months. They agree to this study. They come to our departments at regular intervals.

Exclusion criteria

Exclusion criteria: We excluded the patients who were satisfied with the following conditions. Pioglitazone or incretin related drugs may be added or adjusted in observational period. HbA1c level is more than 10%. Medications about diabetes mellitus were changed for four weeks before this entry.

Design outcomes

Primary

Measure	Time frame
Bone mineral density of femure neck and lumbar spine and biochemical markers of bone turnover	—

Countries

Japan

Contacts

Public ContactArina Miyoshi

Hokkaido University Graduate School of Medicine Rheumatology, Endocrinology and Nephrology

a.miyoshi@med.hokudai.ac.jp011-706-5915

Outcome results