Nasal High Flow Therapy versus Non-Invasive Ventilation for ARDS: open-labeled randomized control study

Nasal High Flow Therapy versus Non-Invasive Ventilation for ARDS: open-labeled randomized control study - NHF vs NIV for ARDS

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000015030

Enrollment

Registered

2014-09-08

Start date

2014-10-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ALI/ARDS based on the AECC criteria

Interventions

NHF group: After randomisation, patients were treated with NHF (60L/min) during 30minutes and switched to NIV(CPAP 5cmH2O) during 30minutes as the crossover study. After the comparison, patients were

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) ALI/ARDS based on the AECC criteria 2) Stay in ICU or ER-ICU 3) PaO2/FIO2 300 or less on the conventional oxygen therapy

Exclusion criteria

Exclusion criteria: 1) PaCO2 45Torr or more and pH 7.35 or less 2) Severe hemodynamic instabilitiy 3) PaO2/FIO2 100 or less 4) Loss of consciousness 5) Uncontrolled heart failure 6) Needed to endtracheal intubation

Design outcomes

Primary

Measure	Time frame
PaO2/FIO2 on NIV(CPAP 5cmH2O) vs. NHF(60L/min)	—

Secondary

Measure	Time frame
Trend of PaO2/FIO2 Borg scale, respiratory rate reduction rate of endotracheal intubation Ventilator free days in 30days Over all survival rate, hospital day hospital mortality Progression Free Survival rate	—

Countries

Japan

Contacts

Public ContactToshiki Yokoyama

Tosei General Hospital Department of Respiratory Medicine and Allergy

toshikiyokoyama1978@hotmail.co.jp+81-561-82-5101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026