vascular endothelial dysfunction
Conditions
Interventions
Ingesting 6 g of quercetin-rich gold-species onion powder daily for 4 weeks.
Ingesting 6 g of ordinary onion powder daily for 4 weeks.
Sponsors
Hokkaido Information University
Okamoto Plant Breeding Co. Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects who agree to participate in the current study with a written informed consent.
Exclusion criteria
Exclusion criteria: (1) Subjects who are pregnant or under lactation, or ones who would be expected to be pregnant during the study. (2) Subjects with unusually high and/or low blood pressure, or with abnormal hematological data, or abnormal urine test data. (3) Subjects who are under medication or receive treatment for chronic ailments (especially cancer, cardiovascular disease, diabetes, dyslipidemia, hypertension etc.) (4) Subjects who regularly use drugs (especially blood coagulation inhibitor, drugs to treat diabetes, drugs to treat dyslipidemia, antihypertensive drugs etc.) (5) Subjects with a history of allergy to medicine and food, especially onions (6) Heavy smokers and alcohol addicts, or subjects with irregular food habits. (7) Subjects who are suffering from severe cardiac disease, liver disease, renal disease, gastrointestinal disease etc. (8) Subjects who have undergone major surgery such as gastrectomy, gastrointestinal suture surgery, intestinal resection or any majo surgery in the digestive system. (9) Subjects with serious anemia. (10) Subjects who have blood coagulation disorders. (11) Subjects who are suspected of acute infectious disease morbidity such as influenza. (12) Subjects who donate 400ml whole blood within 12 weeks or who donate 200ml whole blood within 4 weeks or who donate plasma or platelets within 2 weeks prior to this study. (13) Subjects who are presently participating in other clinical trials. (14) Subjects who are not eligible due to physician's judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting and post-prandial effect on FMD (flow-mediated vasodilation) | — |
Secondary
| Measure | Time frame |
|---|---|
| Body composition (weight, BMI, fat percentage, abdominal circumference, blood pressure), blood lipids (T-cho, TG, LDL-cho, HDL-cho, VLDL-cho) blood glucose (FBG, HbA1c), blood coagulation system (platelet aggregation, PT, APTT, thrombotest), high sensitivity CRP (hsCRP), VAS questionnaire (fatigue, sleep, defecation frequency etc.) | — |
Countries
Japan
Contacts
Public ContactDir. Prof. Jun Nishihira, M.D.
Hokkaido Information University Health Information Science Center
Outcome results
None listed