epidermolysis bllosa
Conditions
Interventions
skin transplantation using punch grafting from natural gene therapy area to refractory ulcer
Sponsors
Hokkaido University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients diagnosed with epidermolysis bullosa (junctional or dystrophic type)and fulfills as follows: 1.Patient aged 6 years old and up. 2.Patient whose responsible gene for epidermolysis bullosa has been identified. 3.Patient with the skin area in which a natural gene therapy occur. 4.Patients with intractable skin ulcers of bigger than 5 cm2 in size which last for more than 2 weeks. 5.Patient who agreed with genetic ecamination of the skin. 6.Patients who agreed with written informed consent after satisfactory explanation.
Exclusion criteria
Exclusion criteria: 1.Patient who has participated in other clinical trials in recent 3 months. 2.Patient who is participating or will participate in other clinical trials. 3. Patients with malignancy except skin malignancy. 4.Patients with pregnancy 5.The patient who may suffer an unjust disadvantage by not participating in this research. 6.Other patients who are evaluated not to be suitable for this research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We evaluate the rate of reepithelialization for the 4th week after the last grafting (%) | — |
Countries
Japan
Contacts
Public ContactYasuyuki Fujita
Hokkaido University Graduate School of Medicine Department of Dermatology
Outcome results
None listed